The risk of cancer associated with immunosuppressive therapy for skin diseases
نویسندگان
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Review of the literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Infl ammatory skin diseases commonly treated with photochemotherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Psoriasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Atopic dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Palmoplantar pustulosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Chronic hand eczema . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Skin-associated malignancies treated with photochemotherapy. . . . . 15 Cutaneous T cell lymphomas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Human skin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 UV radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Th e physical properties of UV radiation . . . . . . . . . . . . . . . . . . 17 Th e biological eff ects of UV radiation . . . . . . . . . . . . . . . . . . . . . 18 Environmental factors aff ecting UV radiation . . . . . . . . . . . . 19 UV radiation and cutaneous carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . 19 Chromophores and DNA damage. . . . . . . . . . . . . . . . . . . . . . . . . 19 Mechanisms involved in carcinogenesis. . . . . . . . . . . . . . . . . . . 20 UV radiation and immunosuppression . . . . . . . . . . . . . . . . . . . 21 Skin cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Basal cell carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Squamous cell carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Malignant melanoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Photochemotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 PUVA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Carcinogenic eff ects of systemic PUVA therapy . . . . . . . . . . . 28 Other phototherapy regimens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
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